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Abpromise
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Get better batch-to-batch reproducibility with a recombinant antibody
Anti-IFNAR2 antibody [EPR24706-26] (ab308498)
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-IFNAR2 antibody
See all IFNAR2 primary antibodies -
Description
Rabbit polyclonal to IFNAR2
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Host species
Rabbit
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Tested applications
Suitable for: ELISA, ICC/IF, WBmore details
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Species reactivity
Reacts with: Human
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Immunogen
A synthetic peptide corresponding to C terminal residues of human IFNAR2 (Interferon-alpha/beta receptor beta chain precursor)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid
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Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
Purity
Immunogen affinity purified
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Purification notes
Purified by antigen specific affinity chromatography.
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Clonality
Polyclonal
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Isotype
IgG
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Research areas
- Immunology
- Innate Immunity
- Cytokines
- Interferons
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- STATs
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- STATs
- Microbiology
- Organism
- Virus
- RNA Virus
- ssRNA positive strand virus
- SARS Coronavirus
- Cancer
- Tumor immunology
- Cytokines
- Interferons
Associated products
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Compatible Secondaries
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Isotype control
- Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
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Recombinant Protein
- Recombinant Human IFNAR2 protein (Fc Chimera) (ab83680)
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab56070 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | Use at an assay dependent concentration. | |
| ICC/IF | (1) | Use at an assay dependent concentration. |
| WB | Use at an assay dependent concentration. Predicted molecular weight: 57 kDa. Two hour incubation. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
| Notes |
|---|
| ELISA |
| ICC/IF |
| WB Two hour incubation. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
Target
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Function
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
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Tissue specificity
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
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Sequence similarities
Belongs to the type II cytokine receptor family.
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Post-translational
modificationsPhosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated. -
Cellular localization
Secreted and Membrane.
- Information by UniProt
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Database links
- Entrez Gene: 3455 Human
- Omim: 602376 Human
- SwissProt: P48551 Human
- Unigene: 708195 Human
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Alternative names
- Human interferon alpha/beta receptor antibody
- IFN alpha REC antibody
- IFN R antibody
see all
Protocols
Click here to view the general protocols
Datasheets and documents
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SDS download
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Datasheet download
Download
References (8)
Publishing research using ab56070? Please let us know so that we can cite the reference in this datasheet.
ab56070 has been referenced in 8 publications.
- Deng Y et al. Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses. EBioMedicine 70:103477 (2021). PubMed: 34284174
- Lundtoft C et al. Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling. PLoS Genet 16:e1009199 (2020). PubMed: 33104735
- Lloyd AF et al. Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nat Neurosci 22:1046-1052 (2019). PubMed: 31182869
- Cheng M et al. Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression. J Biol Chem 293:5975-5986 (2018). PubMed: 29496996
- Yang Q et al. Interferon-a inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh-7 cells transfected with hepatitis B virus X gene-expressing lentivirus. Exp Ther Med 14:5924-5930 (2017). PubMed: 29285141
- Happold C et al. Interferon-ß induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells. Mol Cancer Ther 13:948-61 (2014). PubMed: 24526161
- Hong XX & Carmichael GG Innate immunity in pluripotent human cells: attenuated response to interferon-ß. J Biol Chem 288:16196-205 (2013). Human . PubMed: 23599426
- Ghosh D et al. A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. Proc Natl Acad Sci U S A 105:11673-8 (2008). IP ; Human . PubMed: 18687895
Customer reviews and Q&As
